UP163

UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 (HY-13259) -induced TDP-43 aggregates[1].

Product Specifications

CAS Number

[591242-60-3]

UNSPSC

12352005

Target

P97

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/up163.html

Purity

98.08

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CO1)OCCN(C2=NS(=O)(C3=C2C=CC=C3)=O)C4=CC=C(C=C4)Cl

Molecular Formula

C20H15ClN2O5S

Molecular Weight

430.86

References & Citations

[1]Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134 (14) :e169039.