MDM2/4-p53-IN-2

MDM2/4-p53-IN-2 (2q) is a dual MDM2 and MDM4 antagonist that potently disrupts their interactions with p53, with IC50 values of 70.7 nM and 81.4 nM, respectively. This reactivation of p53 function induces cell cycle arrest and apoptosis, supporting its investigation as a potential anticancer agent in both cellular and animal model studies.