SJ988497
SJ988497 is a PROTAC molecule that degrades JAK2 and the neosubstrate GSPT1 via CRBN recruitment. It potently suppresses the proliferation of CRLF2-rearranged acute lymphoblastic leukemia (ALL) cells in vitro, making it a valuable research tool for targeted protein degradation studies in oncology.
Product Specifications
CAS Number
2595365-41-4
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCCCNC (=O) C4=CC=C (NC5=NC (=C6C (=N5) NC=C6) C7=CN (CCC) N=C7) C=C4
Molecular Formula
C36H36N10O5
Molecular Weight
688.74
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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