RMC-6291

RMC-6291 is a potent, orally bioavailable KRASG12C (ON) inhibitor that exerts its antitumor effect by spatially blocking effector binding to prevent downstream ERK signaling. It induces apoptosis in KRASG12C-mutant cell lines like H358 and shows activity in preclinical in vivo models, supporting its investigation in oncology research.

Product Specifications

CAS Number

2641998-63-0

Product Name Alternative

RMC6291, RMC 6291, 2775304-30-6, Apoptosis, KRAS G12C

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.73% (May vary between batches)

Solubility

DMSO:80 mg/mL (79.03 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (3.26 mM)

Smiles

O=C (C#CC (N (C) C) (C) C) N1CCC (F) (C (=O) N (C) C (C (=O) NC2C (=O) N3NC (C (=O) OCC (C) (C) CC=4C5=CC (=CC=C5N (C4C=6C=CC=NC6C (OC) C) CC) N7CCOC (C7) C2) CCC3) C (C) C) CC1