NRX-0492
NRX-0492 is a potent, orally bioavailable BTK degrader that recruits the Cereblon E3 ligase to induce proteasomal degradation of BTK with sub-nanomolar DC50/DC90 values. This mechanism potently inhibits BCR signaling and related functions, making it a valuable tool for investigating BTK-dependent pathways in both cellular and animal models of B-cell malignancies and autoimmune diseases.
Product Specifications
CAS Number
2416130-57-7
Field of Research
Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=C (C2) N4C[C@H] (CN5CCC (CC5) C6=CC=C (NC7=NC (=CN=C7C (N) =O) N8C[C@@H] (CCC8) N9CCN (C) C9=O) C=C6) CC4
Molecular Formula
C43H51N11O6
Molecular Weight
817.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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