MC-GGFG-AM- (10Me-11F-Camptothecin)
MC-GGFG-AM- (10Me-11F-Camptothecin) is a linker-payload conjugate for constructing ZW251, a GPC3-targeting antibody-drug conjugate (ADC) . This ADC utilizes a cleavable GGFG linker to deliver a camptothecin topoisomerase I inhibitor, demonstrating potent in vitro activity including internalization and bystander killing in hepatocellular carcinoma models.
Product Specifications
CAS Number
2873460-70-7
Field of Research
Molecular Biology
Smiles
C (NC (OCCOCNC (CNC ([C@H] (CC1=CC=CC=C1) NC (CNC (CNC (CCCCCN2C (=O) C=CC2=O) =O) =O) =O) =O) =O) =O) C3=C4C (C=5N (C4) C (=O) C6=C (C5) [C@] (CC) (O) C (=O) OC6) =NC=7C3=CC (C) =C (F) C7
Molecular Formula
C51H56FN9O14
Molecular Weight
1038.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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