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MM-401 TFA

MM-401 (TFA) is a potent and selective inhibitor of the MLL1 methyltransferase, disrupting the MLL1-WDR5 interaction with an IC50 of 0.32 μM. This small molecule induces cell cycle arrest, apoptosis, and differentiation in vitro, making it a valuable chemical probe for studying MLL-rearranged leukemias.

Product Specifications

CAS Number

1442106-11-7

Field of Research

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation

Smiles

C (C (O) =O) (F) (F) F.O=C1[C@H] (NC (=O) [C@H] (CC) NC (=O) [C@H] (CCCNC (=N) N) NC (=O) [C@@] (NC (C (C) C) =O) (C) CCCCN1) C2=CC=CC=C2

Molecular Formula

C31H47F3N8O7

Molecular Weight

700.75

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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