Dehydrobruceine B
Dehydrobruceine B is a quassinoid from Brucea javanica that synergizes with Cisplatin to promote mitochondrial apoptosis. It functions by upregulating AIF and Bax while suppressing the Keap1-Nrf2 pathway. This compound is utilized in cancer research for studying combination therapies in both cellular and animal models.
Product Specifications
CAS Number
53730-90-8
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
C (OC) (=O) [C@]12[C@]3 ([C@]4 ([C@@] ([C@]5 (C) C (C[C@]4 (OC (=O) [C@@H]3OC (C) =O) [H]) =C (C) C (=O) C (O) =C5) ([C@@H] (O) [C@@H]1O) [H]) CO2) [H]
Molecular Formula
C23H26O11
Molecular Weight
478.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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