L-threo-3-Hydroxyaspartic acid
Product Specifications
UNSPSC Description
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].
Target Antigen
EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-threo-3-hydroxyaspartic-acid.html
Purity
98.80
Solubility
10 mM in DMSO|1M NaOH : 14.91 mg/mL (ultrasonic;warming)
Smiles
N[C@@H]([C@H](O)C(O)=O)C(O)=O
Molecular Weight
149.10
References & Citations
[1]Hara
R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient
Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor
A3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54|[2]Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100801/L-threo-3-Hydroxyaspartic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100801/L-threo-3-Hydroxyaspartic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7298-99-9
Available Sizes
Curated Selection
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