L-threo-3-Hydroxyaspartic acid

L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].

Product Specifications

CAS Number

[7298-99-9]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-threo-3-hydroxyaspartic-acid.html

Purity

98.80

Solubility

10 mM in DMSO

Smiles

N[C@@H]([C@H](O)C(O)=O)C(O)=O

Molecular Formula

C4H7NO5

Molecular Weight

149.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Hara R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3 (2) . Appl Environ Microbiol. 2015 Jun;81 (11) :3648-54|[2]Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67 (11) :2115-27.