Deoxyviolacein

Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein (HY-119809) that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/mL) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml.

Product Specifications

CAS Number

[5839-61-2]

UNSPSC

12352005

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/deoxyviolacein.html

Smiles

O=C1NC(C=CC=C2)=C2/C1=C3C(NC(C4=CNC5=C4C=CC=C5)=C\3)=O

Molecular Formula

C20H13N3O2

Molecular Weight

327.34

References & Citations

[1]Jiang, et al. Pathway redesign for deoxyviolacein biosynthesis in Citrobacter freundii and characterization of this pigment. Appl. Microbiol. Biotechnol. 94 (6), 1521-1532 (2012) .