AUY 954 (hydrochloride)
AUY 954 hydrochloride is a potent and selective sphingosine-1-phosphate (S1P (1) ) receptor agonist, exhibiting significant immunomodulatory activity. AUY 954 hydrochloride induces a profound and reversible reduction of circulating lymphocytes upon oral administration. AUY 954 hydrochloride has demonstrated efficacy in prolonging cardiac allograft survival when used in combination with RAD001 in a stringent transplantation model. AUY 954 hydrochloride effectively prevents experimental autoimmune neuritis in rats, showcasing its therapeutic potential in autoimmune conditions.
Product Specifications
CAS Number
[820240-78-6]
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/auy-954-hydrochloride.html
Smiles
FC(C1=CC(C2=CC3=CC(CNCCC(O)=O)=CC=C3S2)=CC=C1C4=CC=CC=C4)(F)F.Cl
Molecular Formula
C25H21ClF3NO2S
Molecular Weight
491.95
References & Citations
[1]A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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