GB-88
GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM[1].
Product Specifications
CAS Number
[1416435-96-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gb-88.html
Purity
99.05
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O=C([C@H]([C@@H](C)CC)NC([C@H](CC1CCCCC1)NC(C2=CC=NO2)=O)=O)N3CCC4(C=CC5=C4C=CC=C5)CC3
Molecular Formula
C32H42N4O4
Molecular Weight
546.70
Precautions
H315, H319, H335
References & Citations
[1]Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) . Br J Pharmacol. 2012 Mar;165 (5) :1413-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
Available Sizes
Curated Selection
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