PROTAC ER Degrader-2
PROTAC ER Degrader-2 is a key synthetic intermediate for constructing PAC, an antibody-conjugatable molecule that combines ADC linker and PROTAC technologies. The resulting PAC demonstrates enhanced degradation of estrogen receptor-alpha (ERα) in research settings compared to the unconjugated PROTAC, supporting investigations into targeted protein degradation.
Product Specifications
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
CC/C (C1=CC=CC=C1) =C (C2=CC=C (OCCN (C) C (COCCOCCNC (C3=CC=C (C (N4[C@@H] (C) [C@H] (NC ([C@H] (C) N (C (OC (C) (C) C) =O) C) =O) C (N (CC5=C (OC) C=CC6=C5C=CC=C6) C7=C4C=C (C#N) C=C7) =O) =O) C=C3) =O) =O) C=C2) \C8=CC=C (OCC9=CC=C (NC ([C@@H] (NC ([C@H] (C (C) C) N) =O) CCCNC (N) =O) =O) C=C9) C=C8
Molecular Formula
C89H104N12O15
Molecular Weight
1581.85
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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