SNIPER (ABL) -015
SNIPER (ABL) -015 is a heterobifunctional degrader that conjugates the ABL inhibitor GNF5 to the IAP ligand MV-1. It effectively induces the degradation of BCR-ABL with a DC50 of 5 μM, providing a useful chemical tool for targeted protein degradation research in oncology, both in vitro and in vivo.
Product Specifications
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NCCOCCOCCOCCNC ([C@@H] (NC ([C@H]1N (C ([C@H] (C2CCCCC2) NC ([C@H] (C) NC) =O) =O) CCC1) =O) C (C3=CC=CC=C3) C4=CC=CC=C4) =O) C5=CC=CC (C6=NC=NC (NC7=CC=C (OC (F) (F) F) C=C7) =C6) =C5
Molecular Formula
C58H70F3N9O9
Molecular Weight
1094.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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