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5-Monobutyl methotrexate

5-Monobutyl methotrexate is a research-grade small molecule functioning as an antimetabolite and immunosuppressant. It acts by inhibiting tetrahydrofolate dehydrogenase, thereby blocking tetrahydrofolate-dependent DNA synthesis. This compound is utilized in biochemical and cancer research, including in vitro studies of antifolate mechanisms.

Product Specifications

CAS Number

66147-31-7

Field of Research

Pharmacology & Drug Discovery

Smiles

NC=1C2=C (N=CC (CN (C) C3=CC=C (C (N[C@@H] (CCC (OCCCC) =O) C (O) =O) =O) C=C3) =N2) N=C (N) N1

Molecular Formula

C24H30N8O5

Molecular Weight

510.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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