Bafilomycin B1

Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A) -induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL) -induced accumulation of lipid droplets[1][2][3].

Product Specifications

CAS Number

[88899-56-3]

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Antibiotic; Bacterial; Fungal; Proton Pump

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bafilomycin-b1.html

Purity

98.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O

Molecular Formula

C44H65NO13

Molecular Weight

815.99

Precautions

H300+H310+H330

References & Citations

[1]Shacka, J. J., et al., (2006) . Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy, 2 (3), 228–230.|[2]Pivtoraiko, V. N., et al., (2010) . Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of neurochemistry, 114 (4), 1193–1204.|[3]Naganuma, S., et al., (1992) . Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochimica et biophysica acta, 1126 (1), 41–48.