PROTAC IRAK4 degrader-2
PROTAC IRAK4 Degrader-2 is a potent and selective degrader of IRAK4, demonstrating DC50 values of 36 nM and 151 nM for protein knockdown in PBMCs. It effectively suppresses cytokine production in vitro and serves as a valuable chemical tool for studying IRAK4 biology in oncology and immunology research.
Product Specifications
CAS Number
2374122-27-5
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CC[C@H]1[C@@H] (COc2ncc (C#CCN3CCC4 (CC3) CCN (CC4) c3ncc (cn3) C (=O) N[C@H] (C (=O) N3C[C@H] (O) C[C@H]3C (=O) NCc3ccc (cc3) -c3scnc3C) C (C) (C) C) c3cc (C (N) =O) c (OC) cc23) NC (=O) [C@H]1F
Molecular Formula
C57H68FN11O8S
Molecular Weight
1086.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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