JPS016
JPS016 is a benzamide-based VHL-recruiting PROTAC that potently degrades HDAC1 and HDAC2. This degradation leads to widespread gene expression changes and induces apoptosis in cellular models like HCT116 cells, supporting its use in epigenetic and cancer research.
Product Specifications
CAS Number
2669785-77-5
Field of Research
Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) COCCCCCCCCCOCC (=O) Nc2ccc (cc2) C (=O) Nc2ccccc2N) C (C) (C) C) cc1
Molecular Formula
C48H63N7O8S
Molecular Weight
898.12
Storage Conditions
-20°C
Notes
For research use only.
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