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JPS016

JPS016 is a benzamide-based VHL-recruiting PROTAC that potently degrades HDAC1 and HDAC2. This degradation leads to widespread gene expression changes and induces apoptosis in cellular models like HCT116 cells, supporting its use in epigenetic and cancer research.

Product Specifications

CAS Number

2669785-77-5

Field of Research

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Smiles

Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) COCCCCCCCCCOCC (=O) Nc2ccc (cc2) C (=O) Nc2ccccc2N) C (C) (C) C) cc1

Molecular Formula

C48H63N7O8S

Molecular Weight

898.12

Storage Conditions

-20°C

Notes

For research use only.

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