NX-5948

NX-5948 is a brain-penetrant, orally available PROTAC degrader that targets Bruton's tyrosine kinase (BTK) for cereblon-mediated degradation. This molecule demonstrates anti-inflammatory and anti-tumor activity by inhibiting B-cell activation, supporting research in autoimmune diseases and B-cell malignancies in both cellular and animal models.

Product Specifications

CAS Number

2649400-34-8

Product Name Alternative

BTK-IN-24, NX5948

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.29% (May vary between batches)

Solubility

DMSO:40 mg/mL (49.57 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.09 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

N (C=1N=C (C=NC1C (N) =O) N2C[C@@H] (CCC2) N3C (=O) N (C) CC3) C4=CC=C (C=C4) C5CCN (CC6CCN (CC6) C=7C=CC (C (N[C@@H]8C (=O) NC (=O) CC8) =O) =NC7) CC5