CZh226
CZh226 is a highly selective PAK4 inhibitor with a Ki of 9 nM, showing over 300-fold selectivity against PAK1. It potently suppresses the migration and invasion of A549 lung cancer cells in vitro by modulating PAK4/LIMK1/cofilin signaling pathways, making it a valuable tool for oncology and metastasis research.
Product Specifications
Smiles
O=C (N1C[C@@H] (C) NCC1) C2=NC3=CC=C (Cl) C=C3C (NC4=NNC (C5CC5) =C4) =N2
Molecular Formula
C20H22ClN7O
Molecular Weight
411.89
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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