MAO-B-IN-18

MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures[1].

Product Specifications

UNSPSC

12352005

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mao-b-in-18.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(COC2=CC=C(C=C2)C3=NOC(C4=CC=C5NN=CC5=C4)=N3)=CC(OC)=C1OC

Molecular Formula

C25H22N4O5

Molecular Weight

458.47

References & Citations

[1]Mariagrazia Rullo, et al. Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors. Eur J Med Chem. 2023 Jul 5;255:115352.|[2]Mariagrazia Rullo, et al. Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors. Eur J Med Chem. 2023 Jul 5;255:115352.