N-didesmethyl Loperamide
N-Desmethyl Loperamide is a metabolite of loperamide that inhibits guinea pig myenteric plexus contractions (IC50 = 370 nM) and acts as a chloroquine chemosensitizer against resistant P. falciparum (EC50 = 482 nM), while showing low cytotoxicity in vascular smooth muscle cells (IC50 >10,000 nM) . This compound is a useful research tool for studying opioid receptor pharmacology and antimalarial combination therapies in vitro.
Product Specifications
CAS Number
66164-06-5
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
NC (C (C1=CC=CC=C1) (C2=CC=CC=C2) CCN3CCC (C4=CC=C (Cl) C=C4) (O) CC3) =O
Molecular Formula
C27H29ClN2O2
Molecular Weight
448.98
Storage Conditions
-20°C
Notes
For research use only.
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