S1PL-IN-31
S1PL-IN-31 is a dual S1P lyase (IC50=210 nM) and Smoothened receptor antagonist (IC50=440 nM) . It demonstrates in vivo efficacy in an EAE rat model, reducing lymphocytic infiltration and attenuating disease symptoms, highlighting its research utility in neuroinflammation and autoimmune studies.
Product Specifications
CAS Number
1538574-95-6
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Smiles
C[C@@H] (N (C1=CC=C (C=N1) C#N) CC2) CN2C3=NN=C (C4=C3C=C (C=C4) Cl) CC5=CC=CC=C5
Molecular Formula
C26H23ClN6
Molecular Weight
454.95
Storage Conditions
-20°C
Notes
For research use only.
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