(+) -JQ1 maleimide
(+) -JQ1 maleimide is a covalent probe designed for the COFFEE method, enabling targeted BRD4 degradation. It facilitates VHL ligase engagement via its maleimide group and PEG2 linker, leading to intracellular BRD4 ubiquitination and proteasomal clearance in cellular studies. This tool is valuable for probing BET protein function and PROTAC mechanism research.
Product Specifications
Smiles
ClC1=CC=C (C2=N[C@@H] (CC (NCCOCCOCCNC (CCCCCN3C (C=CC3=O) =O) =O) =O) C4=NN=C (C) N4C5=C2C (C) =C (C) S5) C=C1
Molecular Formula
C35H42ClN7O6S
Molecular Weight
724.27
Storage Conditions
-20°C
Notes
For research use only.
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