SJ 11646

SJ 11646 is a potent, dasatinib-based PROTAC degrader of lymphocyte-specific protein tyrosine kinase (LCK) with a phenyl glutarimide cereblon binder. It demonstrates potent cytotoxicity in LCK-activated T-ALL cell lines and primary samples in vitro and shows anti-leukemic efficacy in patient-derived xenograft models in vivo, supporting its study in T-cell malignancy research.