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EIF4A i28

EIF4A i28 is a potent, RNA-competitive inhibitor of the eukaryotic initiation factor 4A (eIF4A) with an IC50 of 8.60 μM in ATPase assays. It demonstrates potent anti-proliferative activity in BJAB Burkitt lymphoma cells (EC50 = 0.46 μM) and serves as a valuable chemical probe for studying translation initiation in cancer research.

Product Specifications

CAS Number

2861994-92-3

Smiles

CCCCC1=CC=C (C2=CC=C (C3=NC4=CC=C (C=C4C (C (O) =O) =C3) [N+] ([O-]) =O) O2) C=C1

Molecular Formula

C24H20N2O5

Molecular Weight

416.43

Storage Conditions

-20°C

Notes

For research use only.

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