HDAC4 CHDI Degrader 11
HDAC4 CHDI Degrader 11 is a potent and selective PROTAC degrader of HDAC4, demonstrating low nanomolar DC50 values in Jurkat and Huntington's disease model cells. Its bifunctional design links a class IIa HDAC inhibitor to a VHL ligand. This tool compound is useful for probing HDAC4 biology in oncology and neurodegenerative disease research, with efficacy enhanced by co-administration of P-gp inhibitors like Elacridar in certain cell lines.
Product Specifications
Field of Research
Epigenetics & Chromatin
Smiles
O=C (NCC1=CC=C (C=C1) C2=C (N=CS2) C) [C@H]3N (C[C@@H] (C3) O) C ([C@@H] (NC (COCCOCCOCCOCCOCCCCN (C[C@H] (NC (C4=CC=C (C=C4) C5=NOC (C (F) (F) F) =N5) =O) C) CCC) =O) C (C) (C) C) =O
Molecular Formula
C52H73F3N8O11S
Molecular Weight
1075.26
Storage Conditions
-20°C
Notes
For research use only.
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