TM2 TEAD inhibitor
TM2 is a potent, reversible TEAD inhibitor that blocks auto-palmitoylation (IC50: 38 nM TEAD4) and disrupts TEAD-YAP transcriptional activity. It demonstrates significant antiproliferative effects in YAP-dependent cancer cells and potently inhibits the growth of YAP-driven liver organoids in vitro, supporting its investigation as an anticancer therapeutic.
Product Specifications
CAS Number
1008768-41-9
Product Name Alternative
TEAD-IN-8
Field of Research
Musculoskeletal & Connective Tissue Research; Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.91% (May vary between batches)
Smiles
O=C (NC=1C=CC=CC1) N2CCN (C (=O) C=3C=CC=C (OCCC4CCCCC4) C3) CC2
Molecular Formula
C26H33N3O3
Molecular Weight
435.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![(4-Ethyl-5-m-tolyl-4H-[1,2,4]triazol-3-yl-sulfanyl) acetic acid](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
sc-316358 500 mg
(4-Ethyl-5-m-tolyl-4H-[1,2,4]triazol-3-yl-sulfanyl) acetic acid
Sign In for Pricing
View Details 
MBS6125487-01 0.1 mL
Streptococcus pneumoniae, Common C-polysaccharide (FITC)
Sign In for Pricing
View Details MBS6125487-02 5x 0.1 mL
Streptococcus pneumoniae, Common C-polysaccharide (FITC)
Sign In for Pricing
View Details 22428116 3x 1.0 µg
Gp5 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details