TT-012
TT-012 is a selective small molecule inhibitor of MITF that disrupts its dimerization and DNA-binding activity, thereby suppressing MITF-dependent transcription. It demonstrates anti-tumor and anti-metastatic efficacy in melanoma models, such as B16F10 cells, while showing reduced cytotoxicity toward liver and immune cells in vitro and in vivo.
Product Specifications
CAS Number
1164471-33-3
Product Name Alternative
TT 012, TT012, TT-012
Purity
99.91% (May vary between batches)
Solubility
DMSO:100 mg/mL (286.25 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.45 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
N (C (/C=C/C1=CC=CO1) =O) C=2N=C (NC (/C=C/C3=CC=CO3) =O) C=CC2
Molecular Formula
C19H15N3O4
Molecular Weight
349.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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