ROS-generating agent 1
This small molecule induces cancer cell death by covalently targeting the Sec-498 residue of thioredoxin reductase (TrxR), inhibiting its activity and depleting its protein levels. The consequent ROS generation triggers both apoptosis and ferroptosis, as demonstrated in studies using NCI-H460 non-small cell lung cancer cells.
Product Specifications
CAS Number
2369030-41-9
Product Name Alternative
Ferroptosis, Apoptosis, ROSgenerating agent 1, ROS-generating agent 1, ROS Kinase, ROSKinase, ROS1
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Purity
99.67% (May vary between batches)
Solubility
DMSO:45 mg/mL (109.4 mM)
Smiles
C (=C\1/C (=O) \C (=C\C2=CC (C (F) (F) F) =CC=C2) \CNC1) \C3=CC (C (F) (F) F) =CC=C3
Molecular Formula
C21H15F6NO
Molecular Weight
411.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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