Nurr1 inverse agonist-1

Nurr1 inverse agonist-1 is an indole-based compound that potently inhibits the transcriptional activity of the neuroprotective transcription factor Nurr1, preferentially targeting its monomeric form. This tool compound enables mechanistic studies of Nurr1-mediated gene repression and exploration of its role in dopaminergic neuron health and Parkinson's disease models, both in vitro and in vivo.