Sotuletinib dihydrochloride

Sotuletinib (BLZ945) dihydrochloride is a potent, brain-penetrant CSF1R inhibitor (IC50 = 1 nM) that induces tumor cell apoptosis. It has demonstrated significant anti-tumor efficacy in murine models and is a valuable research tool for studying cancer and neurodegenerative diseases like ALS in both in vitro and in vivo settings.