Tubulin polymerization-IN-53

Tubulin polymerization-IN-53 (4b) is a small molecule inhibitor that disrupts microtubule assembly by targeting β-tubulin, leading to G2/M phase cell cycle arrest. It exhibits antiproliferative activity in vitro, notably against MDA-MB-231 breast cancer cells with an IC50 of 3.24 μM, supporting its use in cancer mechanism and cytology research.