SWTX-143
SWTX-143 is a covalent, pan-TEAD inhibitor that irreversibly occupies the palmitoylation site, blocking YAP/TAZ-TEAD transcriptional activity. This mechanism has shown antitumor efficacy in preclinical models, supporting its use in vitro and in vivo for cancer research, particularly targeting the Hippo signaling pathway.
Product Specifications
CAS Number
2766575-48-6
Field of Research
Stem Cell & Developmental Biology
Smiles
O=C (C=C) NC1CC=2C (N) =CC=CC2N (C3=CC=C (C=C3) C (F) (F) F) C1
Molecular Formula
C19H18F3N3O
Molecular Weight
361.36
Storage Conditions
-20°C
Notes
For research use only.
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