SR-1114
SR-1114 is a novel PROTAC that potently degrades the ENL protein via the CRBN pathway, demonstrating DC50 values of 150 nM in MV4;11, 311 nM in MOLM-13, and 1.65 μM in OCI/AML-2 cells. This degrader is a valuable chemical tool for investigating ENL's role in acute myeloid leukemia (AML) in both cellular and in vivo models.
Product Specifications
CAS Number
2769141-82-2
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C (NC1CCC1) C=2C=CC3=NC (=CN3C2) C=4C=CC=C (C4) NS (=O) (=O) NCCOCCOCCNC (=O) COC5=CC=CC=6C (=O) N (C (=O) C56) C7C (=O) NC (=O) CC7
Molecular Formula
C39H42N8O11S
Molecular Weight
830.86
Storage Conditions
-20°C
Notes
For research use only.
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