Targocil-II

Targocil-II (Compound 2) is an ABC transporter inhibitor with a IC50 value of 137 nM. Targocil-II prevents ATP hydrolysis by binding to allosteric sites of the TM domain. Targocil-II has (antibacterial) activity[1].

Product Specifications

CAS Number

[955918-74-8]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/targocil-ii.html

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C2C(C(C3=CC=C(C=C3)Cl)=CO2)=CC4=C1OC(C(CC(N5[C@@H](CCC5)C(O)=O)=O)=C4C)=O

Molecular Formula

C26H22ClNO6

Molecular Weight

479.91

References & Citations

[1]Matano LM, et al. Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site. J Am Chem Soc. 2017 Aug 9;139 (31) :10597-10600.