Targocil-II
Targocil-II (Compound 2) is an ABC transporter inhibitor with a IC50 value of 137 nM. Targocil-II prevents ATP hydrolysis by binding to allosteric sites of the TM domain. Targocil-II has (antibacterial) activity[1].
Product Specifications
CAS Number
955918-74-8
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/targocil-ii.html
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C2C(C(C3=CC=C(C=C3)Cl)=CO2)=CC4=C1OC(C(CC(N5[C@@H](CCC5)C(O)=O)=O)=C4C)=O
Molecular Formula
C26H22ClNO6
Molecular Weight
479.91
References & Citations
[1]Matano LM, et al. Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site. J Am Chem Soc. 2017 Aug 9;139 (31) :10597-10600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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