Sec61-IN-5

Sec61-IN-5 (Compound 16c) is a potent and selective Sec61 inhibitor, demonstrating cytotoxicity in A549 lung cancer cells (IC50 = 0.27 nM) and blocking protein translocation (IC50 = 0.08 nM) . This tool compound is used in vitro to study secretory pathway biology, ER stress, and cancer cell viability.