SARS-CoV-2-IN-65

SARS-CoV-2-IN-65 (compound 2f) is a potent, orally bioavailable small molecule that reversibly inhibits viral entry. It functions by blocking the SARS-CoV-2 spike RBD:ACE2 interaction and suppressing host TMPRSS2 protease activity, as demonstrated in Calu-3 cell studies. This inhibitor is a useful research tool for investigating ACE2-dependent entry pathways in vitro.