RMC-7977
RMC-7977 is a potent and selective inhibitor targeting the active GTP-bound state of KRAS, HRAS, and NRAS. It is a research tool for investigating KRAS G12C-mutant solid tumors, with demonstrated utility in both in vitro cellular assays and in vivo xenograft models to study oncogenic RAS signaling and therapeutic potential.
Product Specifications
CAS Number
2765082-12-8
Product Name Alternative
KRAS
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.11% (May vary between batches)
Solubility
DMSO:120 mg/mL (138.71 mM)
Smiles
O=C1OCC (C) (C) CC=2C3=CC (=CC=C3N (C2C=4C=C (C=NC4C (OC) C) N5CCN (CC5) C6CC6) CC) C=7N=C (SC7) CC (NC (=O) C8C9COCC89) C (=O) N%10NC1CCC%10
Molecular Formula
C47H60N8O6S
Molecular Weight
865.09
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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