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RIPK1-IN-17

RIPK1-IN-17 is a dual RIPK1/RIPK3 inhibitor that blocks necroptosis by preventing the phosphorylation of RIPK1, RIPK3, and MLKL. It has demonstrated in vivo efficacy by protecting mice from TNF-induced systemic inflammatory response syndrome (SIRS), hypothermia, and lethality, making it a valuable research tool for studying necroptosis in inflammatory disease models.

Product Specifications

CAS Number

3033385-59-7

Product Name Alternative

RIP kinase, RIPkinase

Field of Research

Cell Biology, Signal Transduction

Purity

95.22% (May vary between batches)

Solubility

DMSO:40 mg/mL (75.54 mM)

Smiles

FC1=C (NC (CC2=CC=CC (OC (F) (F) F) =C2) =O) C=C (C3=CC=C (N=C (NC (C4CC4) =O) S5) C5=C3) C=C1

Molecular Formula

C26H19F4N3O3S

Molecular Weight

529.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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