RIPK1-IN-17
RIPK1-IN-17 is a dual RIPK1/RIPK3 inhibitor that blocks necroptosis by preventing the phosphorylation of RIPK1, RIPK3, and MLKL. It has demonstrated in vivo efficacy by protecting mice from TNF-induced systemic inflammatory response syndrome (SIRS), hypothermia, and lethality, making it a valuable research tool for studying necroptosis in inflammatory disease models.
Product Specifications
CAS Number
3033385-59-7
Product Name Alternative
RIP kinase, RIPkinase
Field of Research
Cell Biology, Signal Transduction
Purity
95.22% (May vary between batches)
Solubility
DMSO:40 mg/mL (75.54 mM)
Smiles
FC1=C (NC (CC2=CC=CC (OC (F) (F) F) =C2) =O) C=C (C3=CC=C (N=C (NC (C4CC4) =O) S5) C5=C3) C=C1
Molecular Formula
C26H19F4N3O3S
Molecular Weight
529.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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