(S, R, S) -AHPC-Me-C5-COOH
(S, R, S) -AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S, R, S) -AHPC-Me-C5-COOH can be used in PROTAC DT2216.
Product Specifications
CAS Number
2229976-21-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-me-c5-cooh.html
Purity
96.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C1=CC=C(C2=C(C)N=CS2)C=C1)C)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(O)=O)=O)=O)C[C@H](O)C3
Molecular Formula
C30H42N4O6S
Molecular Weight
586.74
Precautions
H302, H315, H319, H335
References & Citations
[1]Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25 (12) :1938-1947.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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