Anti-inflammatory agent 54
Anti-inflammatory agent 54 (9c), a Coixol derivative, is a potent inhibitor of the NF-κB pathway. It suppresses pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β, demonstrating in vitro activity in LPS-stimulated macrophages (IC50 = 2.4 μM) and in vivo efficacy in murine edema models.
Product Specifications
CAS Number
2924156-46-5
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
C (CNC (/C=C/C1=CC=CO1) =O) N2C=3C (OC2=O) =CC (OC) =CC3
Molecular Formula
C17H16N2O5
Molecular Weight
328.32
Storage Conditions
-20°C
Notes
For research use only.
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