Anti-inflammatory agent 55
Compound 9j, a Coixol derivative, is a potent anti-inflammatory small molecule that inhibits the NF-κB pathway. It suppresses pro-inflammatory mediators like iNOS, TNF-α, IL-6, and IL-1β in vitro (IC50 = 0.8 μM for NO in RAW264.7 cells) and demonstrates efficacy in vivo in murine edema models.
Product Specifications
CAS Number
2924156-51-2
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
O=[N+] (C1=CC=C (O1) /C=C/C (NCCN2C3=CC=C (OC) C=C3OC2=O) =O) [O-]
Molecular Formula
C17H15N3O7
Molecular Weight
373.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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