NF-κB-IN-11

NF-κB-IN-11 is a potent small molecule inhibitor that suppresses TNF-α-induced NF-κB activation and nuclear translocation by reducing phospho-IKK, IκBα, and p65 levels. It demonstrates anti-inflammatory efficacy in a DSS-induced mouse colitis model and shows a high oral MTD (>1852 mg/kg), supporting its use in inflammatory disease research.