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JMJD3/HDAC-IN-1

JMJD3/HDAC-IN-1 (A5b) is a dual inhibitor of JMJD3 and HDAC1 (IC50 = 16 nM) . It modulates histone marks by inducing H3K27 hypermethylation and H3K9 hyperacetylation, promoting apoptosis via caspase-7/PARP cleavage. This compound is used in cancer research to study epigenetic mechanisms and has shown efficacy in inhibiting cell proliferation, migration, and invasion in vitro.

Product Specifications

CAS Number

2883046-06-6

Field of Research

Cell Biology, Epigenetics & Chromatin, Metabolism Research; Epigenetics & Chromatin, Molecular Biology

Smiles

N (CCCCCC (NO) =O) C=1N=C (N=C (C1) N2CCCCCC2) C3=CC=CC=N3

Molecular Formula

C21H30N6O2

Molecular Weight

398.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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