IDH2R140Q-IN-2

IDH2R140Q-IN-2 is a potent, orally bioavailable inhibitor of the IDH2 R140Q mutant, demonstrating an IC50 of 29 nM against the enzyme. It effectively reduces D2HG levels in TF-1 cells (IC50=10 nM) and in tumor tissue, supporting its application in research models of acute myeloid leukemia (AML) .