EGFR-IN-89
EGFR-IN-89 is a potent and selective fourth-generation EGFR inhibitor, demonstrating high activity (IC50 = 10.1 nM) against the Del19/T790M/C797S triple mutation. It shows preferential inhibition of mutant EGFR over the wild-type receptor. This compound is a valuable chemical probe for studying resistance mechanisms in non-small cell lung cancer (NSCLC) in both cellular and animal models.
Product Specifications
CAS Number
2413029-40-8
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C1=C2C (=NC (NC3=CC (F) =C (C=C3) N4CCN (CC) CC4) =N1) NC=C2) C5=C (N (S (C) (=O) =O) C) C=CC=C5
Molecular Formula
C26H31FN8O2S
Molecular Weight
538.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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